The effect of chronic oral administration of verapamil on learning and retrieval in rats using passive avoidance learning task

Authors

  • MSh Safari
  • F Motamedi
  • R Lashgari
  • S Zahedi-Asl
Abstract:

Verapamil is a drug that blocks L-type calcium channels and selectively inhibits calcium ion entry into the central and peripheral nervous system cells. Verapamil is used acutely and chronically in treatment of some cardiovascular and central nervous system disorders. It has also been shown that acute administration of verapamil has no significant effect on learning and memory in rats, but the effect of chronic administration of verapamil on learning and memory has not been fully investigated. Therefore, the purpose of this study was to evaluate the effect of chronic oral administration of verapmil on learning and memory in rats. Male Wistar rats, weighing 150-200 g were used. Rats were treated orally with verapamil for 60 days using oral tube. They were divided into four groups consisting of control and 10, 20, 50 mg/kg of verapamil. After 60 days of treatment with verapamil, animals were trained in a passive avoidance shuttle box, and 24 hours later their memory retrieval were tested. The data indicated that verapamil in all groups had no significant effect on acquisition, but verapamil at a low dose (10 mg/kg) and at a high dose (50 mg/kg) and not at moderate doses (20 mg/kg) significantly reduced memory retrieval (P

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

investigating the effect of motivation and attitude towards learning english, learning style preferences and gender on iranian efl learners proficiency

تحقیق حاضر به منظور بررسی تاثیر انگیزه و نگرش نسبت به یادگیری زبان انگلیسی، ترجیحات سبک یادگیری و جنسیت بر بسندگی فراگیران ایرانی زبان انگلیسی انجام شد. برای این منظور، 154 فراگیر ایرانی زبان انگلیسی در این تحقیق شرکت کردند. سه ابزار جمع آوری داده ها شامل آزمون تعیین سطح بسندگی زبان انگلیسی آکسفورد، پرسشنامه ترجیحات سبک یادگیری براچ و پرسشنامه انگیزه و نگرش نسبت به یادگیری زبان انگلیسی به م...

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes

the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...

The Effect of Ginkgo on Baclofen Induced Amnesia using Passive Avoidance Learning and Memory in Rats

Background & Objective: Ginkgo biloba is an herbal medicine that has a positive effect on improving memory. It prevents oxidative damage in mitochondria and cell death in a variety of Neuropathies. Besides, baclofen is prescribed for its analgesic and anti-inflammatory effects but has negative impact on memory. The objective of this study is to investigate the interaction of ginkgo with GABA b ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume Volume 3  issue Supplement 1

pages  61- 61

publication date 2010-11-20

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023